Isaac is the Head of the AI-CVM Group and Laboratory, which focuses on advancing artificial intelligence (AI) research in cardiovascular medicine. His work centers on developing and applying state-of-the-art machine and deep learning techniques to address a broad spectrum of health-related challenges. He leads efforts in multimodal information analysis, integrating diverse data sources such as clinical text, physiological signals, medical images, videos, electronic health records (EHRs), and omics data. In addition, he is dedicated to developing open-source libraries, software tools, and datasets that foster transparency, collaboration, and innovation in the field.